In fact, the interactions between the somatotropic and the gonadal axes are complex, with both a central stimulatory effect and a peripheral liver resistance to GH mediated by estradiol, leading to different hormonal profiles in male and female subjects [23]; also, a different social and psychological impact of the acromegaly-related facial changes could justify this sex gap in anxiety and depression scores. The gene discussed is GH1; the disease is depressive disorder.