AKT1 and metabolic dysfunction-associated steatohepatitis: Although much evidence indicates that activation of the PI3K/AKT pathway is associated with marked accumulation of intracellular lipid droplets and promotion of NASH to fibrosis, some studies have revealed that PI3K/Akt activation is beneficial for ameliorating insulin resistance, oxidative stress, and lipid accumulation (Li et al. 2018).