FAS and metabolic dysfunction-associated steatotic liver disease: Dysfunction of the ER, the main cellular compartment involved in secretory and transmembrane protein folding, calcium homeostasis, and lipid biogenesis, is involved in metabolically driven NAFLD pathologies through the activation of ER stress signaling, during which the expression of FAS is upregulated (Ashraf and Sheikh 2015; Huang et al. 2010).