Additionally, studies also demonstrated that some natural products ameliorated NAFLD by regulating the PI3K/Akt pathway (Matsuda et al. 2013; Li et al. 2018), which was in accordance with our results that SFN could reduce insulin resistance by activating the PI3K/Akt phosphorylation. The gene discussed is AKT1; the disease is metabolic dysfunction-associated steatotic liver disease.