ANXA5 and neoplasm: The most extensively investigated approach utilised the targeting of phosphatidylserine, which is externalised during apoptosis, with radiolabelled annexin V. Annexin V labelled with 99mTc was demonstrated to bind to and image apoptotic tumour cells [3] and increased tumour uptake of 99mTc-labelled annexin V has been observed in response to chemotherapy [4] and radiotherapy [5].