HTR3A and Pruritus: Effective treatments for neuraxial opioid induced pruritus in humans include partial opioid agonists,1, 4, 19 and nonopioid receptor agents, including 5‐HT3 antagonists,5, 6, 20, 21 propofol,4, 22 prostaglandin modulation,8 and low‐dose continuous naloxone infusions.23