SIRT1 and ischemia reperfusion injury: showed that sirtuin 1 (SIRT1) activation by RSV confers neuroprotection in mice with ischemia–reperfusion injury (IR) via Akt activation and mitochondrial apoptotic suppression with a verified concentration of intravitreal injection, and thus contributed to the understanding of the mechanism of action important for the clinical usage of RSV [131].