TP53 and cancer: As shown in Fig. 4A, in all cancer patients with PIK3CA mutations, the concomitant mutated genes were mainly enriched in the RTK/RAS pathway, PI3K pathway and P53 pathway, which was similar to the results analyzed in BRCA, LUAD and LUSC, while the concomitant mutated genes also significantly enriched in the Wnt pathway in large intestine cancer (Additional file 6: Figure S4).