Through differentially expressed gene analysis, some potential druggable genes that were highly expressed in TAP ≥ 5%, HA + compared with TAP ≥ 5%, HA − tumors were observed, such as AURKA and UBE2C. Previous studies have shown that overexpression of AURKA and UBE2C frequently occurred in GC, promoting cancer cell proliferation or epithelial-mesenchymal transition [48–50]. Here, UBE2C is linked to cancer.