Stromal LGR5 expression was often accentuated immediately beneath the ovarian surface, and notably, this subepithelial LGR5 expression was predominantly observed during the low-grade serous carcinogenesis pathway; five of 15 SAs showed subepithelial LGR5 expression, and the majority of SBTs and LGSCs displayed high levels of LGR5 expression in stromal cells, particularly those adjacent to epithelial tumor cells. This evidence concerns the gene LGR5 and neoplasm.