The infiltration level of CAFs presented a statistically positive relationship with TOP2A expression in various tumor types, namely CESE, ESCA, HNSC, HNSC-HPV−, KICH, KIRC, KIRP, LGG, PCPG, SKCM, SKCM-Metastasis as well as THCA. Here, TOP2A is linked to neoplasm.