The expression of CD274 was positively linked to TOP2A expression in various tumor types, including ACC, BLCA, BRCA, BRCA-Basal, BRCA-LumA, BRCA-LumB, COAD, DLBC, HNSC, HNSC-HPV−, HNSC-HPV+, KICH, KIRC, LGG, LIHC, LUAD, LUSC, OV, PAAD, PRAD, READ, SARC, SKCM, SKCM-Metastasis, SKCM-Primary, STAD, TGCT, THCA, UCEC and UVM (all p values < 0.05). This evidence concerns the gene TOP2A and adrenal cortex carcinoma.