TOP2A and cancer: As showed in Fig. 2A, high expression of TOP2A was related to poor overall survival (OS) in cancers of ACC (p < 0.001), KIRC (p < 0.001), KIRP (p < 0.001), LGG (p < 0.001), LIHC (p = 0.003), LUAD (p = 0.011), MESO (p < 0.001) and PAAD (p = 0.038).