TIMP1 and neoplasm: Similarly, cross-examination of STAD and LGG patient cohorts in GEPIA database, revealed significant correlations between the expression of TIMP1 and that of immune markers in CD8+ T cells, T cells, B cells, monocytes, tumor-associated macrophages, and other macrophages, indicating that TIMP1 may promote the polarization of macrophage in STAD and LGG tumors (Fig. S5 and Table 2).