Considering the entire gene panel of over 200 molecules involved in apoptosis and leukemogenesis, BCL2 was among the most downregulated genes in SEM (Fig. S3), together with tumor drivers and other inhibitors of apoptosis-like HOXA3, MDM2, and VDAC2. However, also prominent tumor suppressors like PTEN and FOXO1 as well as apoptosis-inducers PTRH2 and STK17B were relevantly downregulated (Fig. S3B). The gene discussed is PTRH2; the disease is neoplasm.