Increased BCL-2 activity, as well as dysregulation of further members of the BCL-2 signaling cascade, has previously been shown in acute lymphoblastic leukemia (ALL) and other hematological malignancies like acute myeloid leukemia (AML), chronic lymphoblastic leukemia (CLL), chronic myeloid leukemia, several lymphomas, or myeloma [2, 5]. The gene discussed is BCL2; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.