To assess the effect of T cell ABCA1 and ABCG1 mediated cholesterol efflux pathways on atherosclerosis, CD4CreAbca1fl/flAbcg1fl/fl mice were crossbred with Ldlr−/− mice to generate CD4CreAbca1fl/flAbcg1fl/flLdlr−/− mice and Abca1fl/flAbcg1fl/flLdlr−/− controls. Here, LDLR is linked to atherosclerosis.