NFATC1 and B-cell chronic lymphocytic leukemia: This inconsistency can be explained by two possibilities: (1) NFATc1 target genes are involved in multiple cell functions, while APOBEC3 promotes DNA replication stress, other target genes may suppress this process; (2) Suppression of CLL evolution by NFATc1 and the biological role of NFATc1-controlled APOBEC3 may function at different stages of CLL progression.