In contrast, two downstream effectors, AKT and GSK3β were significantly hypo-phosphorylated in CPD22 treated cells compared to untreated control (Fig. 8E, Supplementary Fig. S8F), in keeping with the inhibitory effects on cell growth in the presence of ILK inhibitor in other cancer lines as previously described [2, 5]. The gene discussed is AKT1; the disease is cancer.