Using chromMAGMA NMOC as an example, a significant promoter (P-value 4.3 × 10−8) at a known breast and ovarian cancer genome-wide significant risk locus at chromosome 9q31 is assigned to SMC2, whereas in MAGMA, SMC2 is not significant (P-value 1.9 × 10−3) (21) (Fig 2D). Here, SMC2 is linked to ovarian cancer.