PFN1 and amyotrophic lateral sclerosis: Accumulating evidence also points to a dysregulation of cytoskeleton dynamics in the disease as mutations in DCTN1 (dynactin subunit 1), PFN1 (profilin 1), and TUBA4 (tubulin alpha 4b) are linked to familial forms of ALS (Castellanos-Montiel et al, 2020).