UBQLN2 and amyotrophic lateral sclerosis: Upon normalization to MAP1B protein abundance, 17 phosphosites were found to be significantly dephosphorylated (log2 ratio ≤ −1) in at least one of the two UBQLN2 ALS mutant LCLs, but only one of these MAP1B phosphosites (T1864) was significantly less phosphorylated in both mutants (Fig 5D).