CDK8 and osteoporosis: Previous studies have shown that the conditional inducible deletion of CDK8 in adult mice exhibits no gross or histopathological defects in many tissues (McCleland et al., 2015), although a global CDK8 knockout leads to embryonic lethality due to a preimplantation defect (Westerling et al., 2007), suggesting that KY-065 treatment will not necessarily cause severe side effects during osteoporosis therapy in adults.