METTL3 and neoplasm: Recently, a new concept of the immune regulatory function of m6A regulators has been proposed.[31] Wang et al[32] reported that the loss of METTL3 or METTL14 increased cytotoxic tumor-infiltrating CD8+ T cells and elevated the secretion of IFN-γ, CXCL9, and CXCL910 in the TME in vivo.