Decorinarrests the cell cycle by downregulating the expression of p21.[38] Previous research has shown that decorin overexpression could dramatically inhibit renal cell carcinoma (RCC) cell line proliferation, migration, and invasion by upregulating p21 and E-cadherin.[39] Tumorigenesis is associated with the inactivation of p21, a protein downstream of p53 that regulates metastasis. This evidence concerns the gene DCN and hereditary clear cell renal cell carcinoma.