ESR1 and breast cancer: According to the network topology parameters, the BC of neurotrophic receptor tyrosine kinase 1 (NTRK1), tumor protein P53 (TP53), cullin 3 (CUL3), estrogen receptor 1 (ESR1), ubiquitin C (UBC), and EGFR is 12 times greater than the median BC of the whole network (1209), which is predicted to be the core protein acted by bailing tablet.