Quercetin can reduce a series of oxidation reaction processes mediated by H2O2, and finally reduce the incidence of vitiligo.[13] Baicalein is a flavonoid active substance extracted from Scutellaria baicalensis, and it can upregulate the expression of GPX4 gene, reduce the level of TFR1, inhibit the iron death of melanocytes, and enhance the antioxidant defense ability of human vitiligo melanocytes.[14] Luteolin is a natural flavonoid with many pharmacological activities, such as anti-inflammatory, antiallergic, antioxidant, and so on. The gene discussed is GPX4; the disease is vitiligo.