Chronic myeloid leukemia (CML) is a hematologic clonal malignancy that is produced by hematopoietic stem cells (HSC).[52] CML, a distinctive cytogenetic abnormality, involves the translocation of the Abelson oncogene 1 (ABL1) on chromosome 9, and breakpoint cluster region (BCR) on chromosome 22, t(9;22)(q34;q11.2), ensuing BCR-ABL gene union well-known Philadelphia positive (Ph+) chromosome[53]. The gene discussed is BCR; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.