BRD2 and Miscarriage: Women with aneuploid spontaneous miscarriage had a reduced ovarian reserve compared with those with euploid miscarriage.[15] Similarly, mothers of children with trisomy 21 have significantly higher serum levels of FSH (indicating low ovarian reserve) than age-matched control subjects.[16,17] La Marca et al[18] found that female age and AMH are independently associated with the rate of euploid blastocysts.