ARG1 and ARG2 share the common function of metabolism in vascular endothelial cells where both isoenzymes metabolize L-arginine to urea and ornithine, resulting in reduced levels of vasoprotective nitric oxide and endothelial dysfunction.[17] Therefore, the findings of our high ARG1 levels and reduced nitric oxide metabolites in the carriers of variant genotypes at ATG7 are in line with the earlier reports. Here, ARG1 is linked to endothelial dysfunction.