Gene encoding human ATG7 protein is located at chromosome 3p25.3,[18] and several polymorphic sites have been identified and associated with the onset of Huntington disease,[19] Breast cancer,[20] and Parkinson disease.[21] In the current study, we demonstrated an association between ATG7 rs1375206 C/G and rs550744886 C/G polymorphisms and CAD in patients originating from Pakistan. This evidence concerns the gene ATG7 and breast cancer.