EDN1 and Hypocalcemia: Osteoblastic bone lesions have been postulated to be stimulated by osteoblast growth factors such as platelet-derived growth factor, insulin-like growth factors, adrenomedullin, transforming growth factor, bone morphogenic proteins, and endothelin-1.[6,29] The increased osteoblastic activity acts as a sink trap resulting in an increased uptake and utilisation of calcium leading to hypocalcaemia.