Because of its potential therapeutic implications, the most intriguing finding in this study was the observation that PrPC levels in a human co-culture model of neurons and astrocytes can be reduced by more than 50% when cells are exposed to non-toxic levels of CGs, a class of compounds that is well-characterized in its clinical use following decades of research and use in patients with heart disease. The gene discussed is PRNP; the disease is heart disorder.