The relationship between CSNK1D and neurodegeneration has been proven in amyotrophic lateral sclerosis where a pharmacological inhibition of CK1-D (the enzyme encoded by CSNK1D) resulted in decreased phosphorylation of TDP-43 (TAR DNA-binding protein 43) by this kinase and enhanced preservation of spinal motor neurons [63]. Here, CSNK1D is linked to amyotrophic lateral sclerosis.