Strikingly, a point mutation (vps35-D620N) that causes autosomal-dominant late-onset PD (Vilariño-Güell et al., 2011; Zimprich et al., 2011; Sharma et al., 2012) hyperactivates LRRK2 through a currently unknown mechanism (Mir et al., 2018). This evidence concerns the gene LRRK2 and Parkinson disease.