A point mutation in vps35, the cargo binding component of the retromer complex, causes autosomal-dominant late-onset familial PD (Vilariño-Güell et al., 2011; Zimprich et al., 2011; Sharma et al., 2012) and potently activates the LRRK2 kinase as assessed by phospho-Rab8 and phospho-Rab10 levels in cells and tissues (Mir et al., 2018). Here, RAB10 is linked to Parkinson disease.