(ii) NEAT1 expression is increased in breast cancer cell lines, and knock-down of NEAT1 shows the same phenotype as ALYREF knock-down, i.e., NEAT1 knock-down reduced cancer cell growth [15, 38], migration and invasion [15] as well as increased apoptosis [38] in vitro and reduced tumor size and metastasis formation in vivo [39, 40]. The gene discussed is NEAT1; the disease is cancer.