EPHA2 and neoplasm: Consistent with a mechanism of enhanced systemic immunity, mice that received combinatorial photoimmunotherapy and anti-PD-1 demonstrated the highest rate of complete responses (defined in this case as absence of both target and distal tumors) (28.6%), and the most substantial distal tumor growth inhibition (TGI) (55.0%) as compared to photoimmunotherapy alone (CR 11.1%; TGI 29.4%) and EphA2-IR700 plus anti-PD-1 (CR 6.7%; TGI 39.8%) (Fig. 7C).