To further characterize inflammatory ICD markers induced by photoimmunotherapy, EGFR-expressing human carcinoma cell lines A431 and FaDu were treated with CTX-IR700 photoimmunotherapy and assessed for the expression or release of DAMP molecules including Hsp70, Hsp90, calreticulin (CRT), ATP, and High Mobility Group Protein B1 (HMGB1) [35–38]. The gene discussed is HMGB1; the disease is carcinoma.