The aim of this study was to investigate the effect of missed basal insulin injections on glycemic control and glucose variability using accurate data from a smart insulin pen device (NovoPen 6) collected in a real-world study.17 The adherence to basal insulin injections was investigated and the association of missed basal insulin doses with glycemic control in patients with T1D was explored, using data from both CGM and the smart insulin pen device. This evidence concerns the gene INS and type 1 diabetes mellitus.