Seven of the genes were downregulated by obesity and reversed by VSG specific weight loss including Ido1, Aldoc, Tmem125, Dgki, Slc7a4, Msc, and Ephb3, while four were inversely regulated with obesity elevating Klhl5, Nek6, Arhgap20, and Hp. The gene discussed is NEK6; the disease is obesity due to melanocortin 4 receptor deficiency.