Obesity has been shown to decrease CD8+ cytotoxic tumor T cells (Wang et al., 2019; Pingili et al., 2021) which was evident, but not significant, in this study comparing lean LFD-Sham to obese HFD-Sham controls (Figure 4B–C). The gene discussed is CD8A; the disease is obesity due to melanocortin 4 receptor deficiency.