LIFR and Stüve-Wiedemann syndrome 1: This skeletal effect is partly transferable to humans, where mutations in the LIFR gene cause Stüve-Wiedemann syndrome (OMIM #610559), characterized by bowing and thickening in the lower limbs and abnormal trabecular bone structure (Cormier-Daire et al., 1998; Dagoneau et al., 2004).