Negative regulators of immune responses in HPV(-) exosomes included MUC-1 and HLA-DRA. MUC-1 (+) exosomes protect HNSCC cells from activated NK cell-mediated lysis. HLA-DRA was the ligand of T cell receptor, and its signal transduction promoted the production of Treg. The gene discussed is MUC1; the disease is head and neck squamous cell carcinoma.