ERBB2 and cancer: Further multivariable regression analysis showed that diffuse type of Lauren classification (OR = 2.28, 95% CI: 1.81–2.45, P=0.014), submucosal invasion (OR = 1.87, 95% CI: 1.32–2.14, P=0.023), and positive HER-2 (OR = 2.41, 95% CI: 2.03–2.71, P=0.008) were independent risk factors for residual cancer (Table 2).