NOTCH3 and CADASIL: Moreover, sequencing revealed that all 10 patients with vascular Notch3 ECD deposits had pathogenic or likely pathogenic variants of NOTCH3, such as p.Arg110Cys, p.Tyr258Cys, p Cys408Arg, p.Cys516Phe, p. Trp1003Cys, and p.Tyr1021Cys, which are reportedly associated with CADASIL (Table 1).