Moreover, a comprehensive analysis of the immune TME of BCC reported an attenuated state of the local immune system in BCC, revealed by a Th2 dominant TME (increased expression of both specific cytokines, such as IL-4, IL-10, and CCL2, and interferon-associated genes), as well as the presence of T-regs and immature dendritic cells (33). This evidence concerns the gene IL4 and skin basal cell carcinoma.