ERBB2 and metastatic melanoma: Few examples of CDx assays are the THXID BRAF Kit which qualitatively detects the presence of BRAF mutations in patients with metastatic melanoma by polymerase chain reaction (PCR) (https://www.biomerieux-diagnostics.com/thxidr-braf), Herceptin, HER2 PharmDx Kit based on immunohistochemistry (IHC) and fluorescence in situ hybridization (FISH) platforms, which determine the overexpression of the HER2 protein and gene in patients with breast cancer (42).