Amongst the new 7 subtypes that were added were based on molecular alterations such as MiT family translocation renal carcinomas, TRCC (originating from the translocation of transcription factor genes TFE3 and TFEB) and succinate dehydrogenase or SDH deficient RCC caused by a biallelic mutation of one of the four subunits of SDH complex; familial predisposition syndrome associated hereditary leiomyomatosis and RCC syndrome associated specific renal disease acquired cystic disease associated RCC. Here, TFE3 is linked to renal cell carcinoma.