SETD2 and renal cell carcinoma: The earliest sequencing data that came out for RCC in 2009 established a higher frequency of mutations in chromatin remodeling genes like lysine demethylase 6A (KDM6A) and SETD2, KDM5C or lysine demethylase 5C and KMT2D or MLL2, and lysine methyltransferase 2D (90).