The earliest sequencing data that came out for RCC in 2009 established a higher frequency of mutations in chromatin remodeling genes like lysine demethylase 6A (KDM6A) and SETD2, KDM5C or lysine demethylase 5C and KMT2D or MLL2, and lysine methyltransferase 2D (90). Here, KMT2D is linked to renal cell carcinoma.