DVL2 and renal cell carcinoma: In addition, Xp11 translocation renal cell carcinoma, in which the transcription factor gene (TFE3) located on chromosome Xp11.2 is fused by translocation to proline-rich mitotic checkpoint control factor (PRCC) or disheveled segment polarity protein 2 (DVL2), is common in pediatric patients with RCC (61).