The most studied genetic event in RCC is the loss of chromosome 3p that leads to mutations in VHL, polybromo1 (PBRM1), BRCA1-associated protein 1 (BAP1), and set domain containing 2 (SETD2) affecting 90% of ccRCC cases (70). This evidence concerns the gene PBRM1 and nonpapillary renal cell carcinoma.