MET and chromophobe renal cell carcinoma: Similarly, in nccRCC, NGS allowed the discovery of unique mutations and somatic copy number alterations (SCNA) in MET proto-oncogene (MET), SETD2, and Neurofibromin 2 (NF2) in pRCC and tumor suppressor genes TP53 and PTEN in chRCC (93, 94).