PDCD1 and colitis: Bacteroides fragilis, Burkholderia cepacia and the Faecalibacterium genus are associated with better response and lower incidence of colitis with anti-CTLA-4, while Bifidobacterium breve and longum, Akkermansia muciniphila, and Faecalibacterium prausnitzii are related with better outcomes with anti-PD-1/PD-L1 (56).