Therefore, the blockade of these checkpoints may increase the anti-tumor activity of the immune system, which is accompanied by the risk of the loss of self-tolerance, leading to the occurrence of irAEs, causing damage to normal cells and tissues.CTLA4 modulates the immune response in theearly stages, while PD-1 acts later in the immunologic cycle (1, 12). This evidence concerns the gene CTLA4 and neoplasm.