In the present study, we observed that infection of LMH cells with FAdV-4 activated a number of DEGs that regulate the apoptosis, apoptosis-fly, and apoptosis-multiple species signaling pathways, mainly containing pro-survival genes e.g., TMBIM6 (Bax inhibitor), BCL2L1 (Bcl-xL), BCL2 apoptosis regulator (BCL2); pro-apoptotic genes e.g., caspase 8 (CASP8), caspase 9 (CASP9), transcription factor subunit (FOS), Jun proto-oncogene, AP-1 transcription factor subunit (JUN), tubulin alpha 1a (TUBA1A), TUBA1B, TUBA1C, and TUBA3E (Figure 5A). This evidence concerns the gene CASP9 and infection.