Indeed, hiPSC-derived cells have been employed in several screens of small molecules hypothesized to impact AD processes, however, the majority of these experiments have been performed in neuronal cells and largely focused on the effects of compounds on Aβ and tau (Brownjohn et al., 2017; Kondo et al., 2017; van der Kant et al., 2019; Cheng et al., 2021). Here, MAPT is linked to Alzheimer disease.