On the other hand, as previously pointed out, because the XCR1+ aDC subset was shown to descend from XCR1+ cDC1 and their maturation in tumor tissues was shown to be dependent on antigen uptake, antigens expressed by mTECHigh may be indeed preferentially acquired by cDC1, which then initiates their maturation to aDC (54, 102). The gene discussed is MPPE1; the disease is neoplasm.