The genes involved in the signature were identified in the single-cell tumor microenvironment atlas(Figure 8C). In a fleeting glimpse, we could see the expression of the gene UBE2D3, UBE2D2, GRN, UBB was ubiquitous in immune-microenvironment in the GBM patients, and UBE2G2, CUL1, and USP4 showed moderate expression in immune cells. This evidence concerns the gene UBE2D3 and neoplasm.