SPDEF and allergic asthma: Also of note, we found that blocking LASI lncRNA expression in CHBEs led to a suppressed induction of MUC5AC mucin expression with no change in transcription factor SPDEF expression, suggesting that CSE-mediated mucin expression may not directly involve the previously observed LASI lncRNA-and SPDEF-mediated mucin upregulation observed in allergic asthma studies (11).