We also investigated of the expression of other lncRNAs such as, ICAM-1-related lncRNA (ICR), which regulates ICAM-1 expression by mRNA stabilization via direct interaction and duplex formation (22), but there was no significant change in ICR levels among COPD tissue samples (Supplementary Figure S1D). Here, ICAM1 is linked to chronic obstructive pulmonary disease.