TGFB1 and asthma: Undoubtedly, the above proteins are responsible for chronic inflammation, bronchial hyperreactivity, myofibroblast activation, fibrosis, bronchial remodeling, and they change the expression of approximately 1000 genes in asthma, especially those of MMPs, PAI-1, CTGF, MCP-1, IL-6, TGF-β, TSP-1, TGFR-1/2, fibronectine, proteoglycans, as well as type I and III collagen (3, 4, 6).