To examine possible infiltration of the core immune cells (CICs) (including B, CD4+T, CD8+T, Neutrophil, Macrophage and Dendritic cells) that would be recruited by the top 50-ranked regulators intersected across all of the three data (see Table 2), we searched them against multiple cancer cohorts, including colon (COAD), kidney (KIRC), liver (LIHC) and lung (LUAD) in database TIMER2.0 (51) at https://cistrome.shinyapps.io/timer. Here, CD8A is linked to cancer.