MYD88 and Sepsis: Such a positive feedback loop is also initiated in MyD88-deficient mice (B) at the early stage of sepsis progression (Table 2; Figures 8–10), but later attenuated owing to the impaired MyD88-assoicated signaling pathways, which keeps a balance between the moderate innate immunity responses and the living status of deficient mice (B), leading to a low mortality rate (24).