Case 5: The PD-L1 expression and PD-1 checkpoint pathway in cancer (mmu05235) is a composite target signaling pathway, which embeds the Toll-like signaling pathway, MAPK signaling pathway, PI3K-Akt signaling pathway, HIF-1 signaling pathway, and T-cell receptor signaling pathway (Figure 7). The gene discussed is AKT1; the disease is cancer.