GSDMD and Yersinia infectious disease: They found loss of Rag-Ragulator significantly inhibited a series of biological processes including the complexIIformation, RIPK1 phosphorylation, and caspase-8 activation, confirming that Rag-Ragulator complex (including RagA, RagC, and Lamtor1-5) actively participates in the regulation of Yersinia infection-induced GSDMD-mediated pyroptosis (105) (Figure 4).