It has been demonstrated that Yersinia infection-induced inhibition of the transforming growth factor β–activated kinase (TAK1) or pharmacological inhibitor of TAK1 by 5Z-7-oxozeaenol (5z7) contributes to the cleavage of GSDMD without the participation of caspase-1/11 (78, 79). The gene discussed is GSDMD; the disease is Yersinia infectious disease.