The activation of NLRP1, NLRP3, NLRC4, and AIM2 inflammasomes were detected in the brain following ischemic stroke. Especially, the NLRC4 inflammasomes mediate the inflammatory response and pyroptosis in microglial cells, as well as the NLRP3 inflammasomes were assembled to increased levels of IL-1β and IL-18 in middle cerebral artery occlusion/reperfusion (MCAO/R). GSDMD participated in the progression of pyroptosis and may be a potential therapeutic target in ischemic brain injury. Here, GSDMD is linked to ischemic stroke.