In cervical cancer, the overexpression of Sirtuin 1 (SIRT1) is related to AIM2 inflammasome response. In addition, anti-inflammatory therapy targeting the IL-1β could significantly reduce lung cancer mortality. GSDMD served as an indispensable component of inflammasome pathway, may be a potential treatment target in several cancer. The gene discussed is AIM2; the disease is lung carcinoma.