As shown in the PPI network, 3 hub genes located at the core of the network with three interactions were identified, including serum/glucocorticoid regulated kinase 1 (SGK1), arrestin beta 1 (ARRB1), and G protein-coupled receptor 183 (GPR183) (Figure 5), and three of them were downregulated in sepsis. The gene discussed is SGK1; the disease is Sepsis.