In addition, colorectal cancer develops from multiple chronic processes from normal epithelium to adenoma and adenocarcinoma and eventually metastasis [26], timely diagnosis and removal of colorectal adenoma before it develops into adenocarcinoma is an important way to prevent colorectal cancer, and this study found that GABRD expression was significantly elevated in colorectal adenoma, suggesting that GABRD can be used as a biomarker for early diagnosis of colorectal cancer. Here, GABRD is linked to adenoma.