INS and Insulin resistance: It was compared to metformin, a hypoglycaemic drug that improved fasting insulin levels (69 ±51), HOMA-IR (1.3 ±0.9), and insulin sensitivity index (7 ± 5.5). Ibanez et al. stated that after one year, insulin resistance (IR), as evaluated by the HOMA-IR level, decreased significantly in the group using SPIOMET(1.2 ± 0.1) compared to the group taking COC (Ethinyl estradiol-Levonorgestrel) (3 ±0.3) [36].