SP1 and acute myeloid leukemia: Curcumin inhibits DNA methylation by covalently blocking the catalytic thiolate of DNMT1 and reducing the expression of tumor suppressor gene Sp1 Transcription Factor (Sp1) and Transcription factor p65 (p65) in acute myeloid leukemia (AML) cell lines in vitro and in vivo (Yu et al., 2013).